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Makoto Inoue Selected Research

Neuralgia (Stump Neuralgia)

8/2015Discovery of a 1-isopropyltetrahydroisoquinoline derivative as an orally active N-type calcium channel blocker for neuropathic pain.
8/2015Discovery of an 8-methoxytetrahydroisoquinoline derivative as an orally active N-type calcium channel blocker for neuropathic pain without CYP inhibition liability.
12/2014Discovery of novel tetrahydroisoquinoline derivatives as orally active N-type calcium channel blockers with high selectivity for hERG potassium channels.
5/2010Evidence for de novo synthesis of lysophosphatidic acid in the spinal cord through phospholipase A2 and autotaxin in nerve injury-induced neuropathic pain.
11/2009Lysophosphatidic acid-3 receptor-mediated feed-forward production of lysophosphatidic acid: an initiator of nerve injury-induced neuropathic pain.
4/2009Evidence for lysophosphatidic acid 1 receptor signaling in the early phase of neuropathic pain mechanisms in experiments using Ki-16425, a lysophosphatidic acid 1 receptor antagonist.
12/2008Simultaneous stimulation of spinal NK1 and NMDA receptors produces LPC which undergoes ATX-mediated conversion to LPA, an initiator of neuropathic pain.
2/2008Autotaxin, a synthetic enzyme of lysophosphatidic acid (LPA), mediates the induction of nerve-injured neuropathic pain.
12/2007Evidence for the tonic inhibition of spinal pain by nicotinic cholinergic transmission through primary afferents.
8/2006Loss of spinal substance P pain transmission under the condition of LPA1 receptor-mediated neuropathic pain.
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Makoto Inoue Research Topics

Disease

26Neoplasms (Cancer)
12/2020 - 02/2002
24Retinal Perforations
03/2022 - 02/2002
22Retinal Detachment (Retinal Detachments)
03/2023 - 02/2002
18Inflammation (Inflammations)
01/2022 - 08/2005
16Epiretinal Membrane (Epiretinal Membranes)
01/2024 - 02/2002
15Neuralgia (Stump Neuralgia)
08/2015 - 03/2003
13Macular Degeneration (Age-Related Maculopathy)
11/2021 - 01/2007
13Infections
01/2021 - 06/2003
11Macular Edema
10/2022 - 02/2004
11Diabetic Retinopathy (Retinopathy, Diabetic)
06/2016 - 05/2003
11Pain (Aches)
01/2010 - 05/2003
10Multiple Sclerosis
01/2023 - 05/2012
9Obesity
04/2024 - 01/2011
9Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental)
01/2023 - 05/2012
9Wounds and Injuries (Trauma)
01/2021 - 05/2002
9Hyperalgesia
08/2015 - 03/2003
9Ischemia
01/2015 - 04/2003
8Cataract (Cataracts)
01/2023 - 11/2004
8Rheumatoid Arthritis
12/2022 - 06/2004
7Alzheimer Disease (Alzheimer's Disease)
08/2023 - 04/2007
7Retinoschisis (Retinoschisis, Juvenile)
06/2022 - 11/2008
7Vitreous Detachment (Posterior Vitreous Detachment)
07/2021 - 02/2007
6Hemorrhage
09/2021 - 11/2005
6Endophthalmitis (Ophthalmia)
01/2020 - 01/2008
6Choroidal Neovascularization
02/2010 - 10/2006
5Colonic Neoplasms (Colon Cancer)
12/2020 - 03/2014
5Renal Insufficiency (Renal Failure)
01/2014 - 05/2002
5Neoplasm Metastasis (Metastasis)
08/2011 - 05/2002
5Schizophrenia (Dementia Praecox)
01/2006 - 01/2002
4Deglutition Disorders (Dysphagia)
04/2024 - 01/2015
4Type 2 Diabetes Mellitus (MODY)
11/2023 - 08/2007
4Xerostomia
01/2023 - 04/2009
4Aspiration Pneumonia
11/2020 - 01/2015
4Edema (Dropsy)
01/2020 - 04/2006
4Vitreous Hemorrhage
09/2015 - 08/2010
4Hypersensitivity (Allergy)
06/2014 - 08/2006
4Atherosclerosis
07/2007 - 07/2002
4Uveitis
01/2007 - 08/2005
4Experimental Melanoma
07/2002 - 04/2002
3Vision Disorders (Hemeralopia)
01/2024 - 11/2013
3Autoimmune Diseases (Autoimmune Disease)
01/2023 - 05/2013
3Retinal Vein Occlusion
10/2022 - 07/2021
3Stroke (Strokes)
05/2022 - 04/2003
3Cough
01/2022 - 09/2013
3Melanoma (Melanoma, Malignant)
01/2022 - 02/2008
3Osteoporosis
10/2019 - 01/2012
3Myopia
12/2018 - 02/2002
3Carcinogenesis
01/2018 - 02/2003
3Neovascular Glaucoma
09/2015 - 01/2008
3Nephrotic Syndrome (Syndrome, Nephrotic)
01/2015 - 08/2008
3Ganglion Cysts (Ganglion)
01/2015 - 08/2006
3Glaucoma
01/2015 - 01/2008
3Acute Kidney Injury (Acute Renal Failure)
06/2012 - 09/2007

Drug/Important Bio-Agent (IBA)

35Retinaldehyde (Retinal)IBA
01/2024 - 02/2002
23Proteins (Proteins, Gene)FDA Link
01/2020 - 06/2003
7CytokinesIBA
01/2022 - 06/2004
7VaccinesIBA
01/2021 - 04/2007
6InflammasomesIBA
01/2022 - 06/2012
6Messenger RNA (mRNA)IBA
01/2017 - 12/2004
6SteroidsIBA
09/2013 - 09/2006
5SolutionsIBA
09/2023 - 05/2002
5AntibodiesIBA
12/2022 - 07/2008
5Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
10/2022 - 06/2007
5Capsaicin (Zostrix)FDA Link
11/2020 - 03/2003
5AntigensIBA
03/2016 - 03/2002
5Fibroblast Growth Factor 2 (Basic Fibroblast Growth Factor)IBA
03/2013 - 04/2006
5lysophosphatidic acidIBA
05/2010 - 02/2008
5Therapeutic UsesIBA
09/2008 - 12/2004
5Type 1 Angiotensin ReceptorIBA
09/2007 - 03/2005
4fibroblast growth factor 21IBA
11/2023 - 01/2019
4Biomarkers (Surrogate Marker)IBA
08/2023 - 04/2006
4Ranibizumab (Lucentis)FDA Link
10/2022 - 01/2019
4InterferonsIBA
01/2021 - 09/2006
4Adrenal Cortex Hormones (Corticosteroids)IBA
08/2013 - 01/2007
4Triamcinolone Acetonide (Azmacort)FDA LinkGeneric
04/2010 - 02/2004
4Analgesics (Analgesic Drugs)IBA
12/2007 - 03/2003
4EndotoxinsIBA
01/2007 - 08/2005
3Infliximab (Remicade)FDA Link
12/2022 - 03/2017
3CT-P13IBA
12/2022 - 03/2017
3Neuroprotective AgentsIBA
01/2019 - 12/2006
3CholesterolIBA
06/2018 - 11/2004
3Matrix Metalloproteinase 2 (Gelatinase A)IBA
03/2016 - 05/2003
3N-Type Calcium Channels (N-Type Calcium Channel)IBA
08/2015 - 12/2014
3Peptides (Polypeptides)IBA
02/2013 - 06/2006

Therapy/Procedure

53Vitrectomy
03/2023 - 02/2002
26Therapeutics
04/2024 - 04/2006
13Lasers (Laser)
12/2021 - 04/2002
10Traction
01/2024 - 11/2008
8Light Coagulation
11/2021 - 01/2008
6Immunotherapy
01/2020 - 09/2006
5Kampo Medicine (Kampo)
04/2024 - 07/2002
5Surgical Instruments (Clip)
01/2024 - 11/2004
5Transjugular Intrahepatic Portasystemic Shunt
10/2014 - 01/2012
5Renal Dialysis (Hemodialysis)
02/2013 - 01/2002
5Cannula
04/2010 - 11/2004
3Intravitreal Injections
01/2019 - 02/2004
3Operative Surgical Procedures
02/2018 - 05/2002
3Ligation
08/2015 - 12/2014
3Peritoneal Dialysis
01/2014 - 02/2007
3Intraocular Lenses (Intraocular Lens)
01/2014 - 10/2005